Lucrezia Borgia, infamous noblewoman of the Renaissance, has outlived three husbands and is now married to Don Alfonso, Duke of Ferrara. After the Borgia’s palace is defaced by vandals, Lucrezia demands the desecrator’s death to avenge the insult. When the noble young soldier Gennaro is arrested for the crime, Lucrezia’s thirst for vengeance and murder sets in motion a tragic chain of events that eventually destroys her enemies and herself.